Long-Acting Naltrexone Effective in Alcohol Use Disorder

Thomas R. Collins

October 04, 2022

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Starting treatment for alcohol use disorder (AUD) with extended-release naltrexone injections in the emergency department (ED) produced a dramatic reduction in alcohol consumption, according to findings presented at the American College of Emergency Physicians (ACEP) 2022 Scientific Assembly.

The results show the feasibility of such a program and underscore the importance of the ED in combating AUD, said the researchers, from the University of California, San Francisco (UCSF).

"According to the National Institute on Alcohol Abuse and Alcoholism, 18% of ED visits had alcohol as a contributing factor — the volume of alcohol-related ED visits has been climbing every year, and it is a significant public health problem," said Maria Raven, MD, MPH, professor of emergency medicine at UCSF. "Right now, we do very little for people who come to the ED with AUD, so it is a missed opportunity to intervene, especially given the volume of visits we see and that our patient population is one that often has significant barriers to accessing outpatient treatment."

The findings come from a 12-week, prospective, single-arm study of ED patients who were actively drinking adults with known or suspected AUD and who had positive scores on a screening test. Of 179 patients who were approached, 32 agreed to enroll; the enrollment yield was 18%.

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